ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

TCF7

Function : transcription factor 7
Description : This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling. [provided by RefSeq, Oct 2016]

Classification  

Super Class Other all-alpha-helical DNA-binding domains
Class High-mobility group (HMG) domain factors
Family TCF-7-related factors
Sub Family None

External references

Ensembl ENSG00000081059
RefSeq NP_003193
Uniprot P36402
Aliases TCF-1
UCSC Gene coordinates chr5:134114702-134148228

External Links

JASPAR MA0769.1
Wikipedia TCF7
WikiGenes TCF7
Transcription Factor Encylopedia TCF7    
GeneCards TCF7
FactorBook TCF7


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for TCF7

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for TCF7