ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

TP53

Function : tumor protein p53
Description : This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

Classification  

Super Class Immunoglobulin fold
Class p53 domain factors
Family p53-related factors
Sub Family None

External references

Ensembl ENSG00000141510
RefSeq NP_001263627
Uniprot P04637
Aliases BCC7, LFS1, P53, TRP53
UCSC Gene coordinates chr17:7668401-7687549

External Links

JASPAR MA0106.3
Wikipedia TP53
WikiGenes TP53
Transcription Factor Encylopedia TP53    
GeneCards TP53
FactorBook TP53


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for TP53

MACS - Datasets excluded for TP53

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for TP53