ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

TWIST1

Function : twist family bHLH transcription factor 1
Description : This gene encodes a basic helix-loop-helix (bHLH) transcription factor that plays an important role in embryonic development. The encoded protein forms both homodimers and heterodimers that bind to DNA E box sequences and regulate the transcription of genes involved in cranial suture closure during skull development. This protein may also regulate neural tube closure, limb development and brown fat metabolism. This gene is hypermethylated and overexpressed in multiple human cancers, and the encoded protein promotes tumor cell invasion and metastasis. Mutations in this gene cause Saethre-Chotzen syndrome in human patients, which is characterized by craniosynostosis, ptosis and hypertelorism. [provided by RefSeq, Aug 2017]

Classification  

Super Class Basic domains
Class Basic helix-loop-helix factors (bHLH)
Family Tal-related factors
Sub Family Twist-like factors

External references

Ensembl ENSG00000122691
RefSeq NP_000465
Uniprot Q15672
Aliases ACS3, BPES2, BPES3, CRS, CRS1, CSO, SCS, SWCOS, TWIST, bHLHa38
UCSC Gene coordinates chr7:19113046-19117671

External Links

JASPAR MA1123.1
Wikipedia TWIST1
WikiGenes TWIST1
Transcription Factor Encylopedia TWIST1
GeneCards TWIST1
FactorBook TWIST1


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for TWIST1

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for TWIST1