ReMap 2018 v1.2

An integrative ChIP-seq analysis of regulatory regions

WRNIP1

Function : Werner helicase interacting protein 1
Description : Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012]

Classification  

Super Class Unknown
Class Unknown
Family Unknown
Sub Family Unknown

External references

Ensembl ENSG00000124535
RefSeq NP_569079
Uniprot Q96S55
Aliases WHIP, bA420G6.2
UCSC Gene coordinates chr6:2765340-2785744

External Links

JASPAR WRNIP1
Wikipedia WRNIP1
WikiGenes WRNIP1
Transcription Factor Encylopedia WRNIP1    
GeneCards WRNIP1
FactorBook WRNIP1


Genomic visualization & Analyses for MACS

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for MACS

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

MACS - Datasets retained for WRNIP1

Genomic visualization & Analyses for JAMM

Datasets
quality
DNA constraint
Motifs UCSC genome
browser

Downloading peaks and sequences for JAMM

All peaks BED file
Merged peaks
(non-redundant peaks)
BED file
Peak sequences FASTA file

JAMM - Datasets retained for WRNIP1